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STRAVIX◊ Tissue
Cryopreserved Umbilical Tissue

SSTRAVIX Tissue is composed of preserved umbilical tissue and retains all native components including Hyaluronic acid. It naturally conforms to complex anatomies, and performs across specialties,* from complex soft tissue reconstruction1 to chronic wounds.

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STRAVIX◊ PL
Lyopreserved Umbilical Tissue

STRAVIX PL Tissue was designed for the realities of today’s OR: fast-paced, high-stakes, and never one-size-fits-all — Delivering the same benefits as STRAVIX◊ Tissue, with the added convenience of room‑temperature storage for easy handling.

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GRAFIX◊ XC
Cryopreserved Placental Membrane

GRAFIX XC Membrane brings the full power of human placental tissue—native cells and an intact extracellular matrix—directly to the wound bed.3,4

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GRAFIX PL◊ XC
Lyopreserved Placental Membrane

GRAFIX PL XC Membrane brings the full power of human placental tissue — native cells and an intact extracellular matrix — directly to the wound bed, with the added convenience of room‑temperature storage.3,4

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OASIS®
Matrix products

OASIS Matrix products are naturally derived from porcine small intestinal submucosa (SIS), similar to human dermis, retaining the complex extracellular matrix of porcine tissue. OASIS provides a natural scaffold that supports cellular migration and vascular growth.5-17

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  1. Lavery LA, Fulmer J, Shebetka KA, et al. The efficacy and safety of Grafix® for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded, clinical trial. .Int Wound J.2014; 11(5): 554-560.
  2. Data on file at Osiris Therapeutics, Inc..
  3. Dhall S, Sathyamoorthy M, Kuang JQ, et al. Properties of viable lyopreserved amnion are equivalent to viable cryopreserved amnion with the convenience of ambient storage. Plos One. 2018; 13 (10): e0204060.
  4. Mamede AC, Carvalho, MJ, Abrantes AM, et al. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res. 2012; 349 (2): 447-458.
  5. Mostow EN, Haraway GD, Dalsing M, et al. Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: A randomized clinical trial."J Vasc Surg. 2005;41(5):837-843.
  6. Cazzell SM, Lange DL, Dickerson JE, Slade HB. The Management of Diabetic Foot Ulcers with Porcine Small Intestine Submucosa Tri-Layer Matrix: A Randomized Controlled Trial Adv Wound Care. 2015;4(12):711-718.
  7. Internal Cook Biotech Document: 97-010 VIIA.
  8. Internal Cook Biotech Document: 97-010 VIIB. 6. Internal Cook Biotech Document: 07-057.
  9. Internal Cook Biotech Document: 00-027. 8. Internal Cook Biotech Document: 98- 084.
  10. Brown B, Lindberg K, Reing J, Stolz DB, Badlyak SF. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng. 2006; 12(3): 519-526.
  11. Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. Tissue Eng. 1996; 2(3): 209-217.
  12. Hodde JP, Janis A, Ernst D, Zopf D, Sherman D, Johnson C. Effects of sterilization on an extracellular matrix scaffold: Part 1. Composition and matrix architecture. J Mater Sci Mater Med. 2007; 18(4): 537-543.
  13. Internal Cook Biotech Document: 96-006.
  14. Hurst RE, Bonner RB. Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy. J Biomater Sci Polym Ed. 2001; 12(11): 1267-1279.
  15. Kinn PM, Holdren GO, Westermeyer BA, et al. Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin. Sci Rep. 2015; 5: 10472. doi: 10.1038/srep10472.
  16. Son ED, Lee JY, Lee S, et al. Topical application of 17 beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. J Invest Dermatol. 2005; 124(6): 1149-61.
  17. Kabelitz D, Schröder J-M (eds): Mechanisms of Epithelial Defense. Chem Immunol Allergy. Basel, Karger, 2005, vol 86, pp 22-41.
  18. McGrath JA, Eady RAJ, Pope FM. Anatomy and organization of human skin. In Burns T, Breathnach S, Cox N, Griffiths C, editors, R

 

*Can be used as a wrap, cover, or barrier